Dermorphin
What do these badges mean?
Evidence tier
- AHuman-validated — Human trials showing positive results and good safety.
- BAnimal-grade — No human trials yet, but solid animal/preclinical evidence of effect and safety.
- CAnecdotal — No human or animal trials — only anecdotal/observational reports.
- DInsufficient evidence — No or insufficient evidence (encyclopedia only — never recommended by the builder).
Safety light
- 🟢 Green — Only mild, manageable side effects; reasonable safety data.
- 🟡 Yellow — Needs active management, has a meaningful contraindication/interaction, or has thin long-term data.
- 🔴 Red — Risk of a hospital-level event — treat with serious caution.
Browse-only — not on the protocol builder's curated shortlist, so the builder won't recommend it.
What is it?
Dermorphin is a naturally occurring opioid heptapeptide first isolated from the skin of Phyllomedusa (South American) frogs. It is an extraordinarily potent selective µ-opioid receptor agonist — the foundational pharmacology paper behind it put its potency at ~752–2,170× the potency of morphine in animal models, with the 0035 deep-research categorization pass summarizing it as ~40× morphine potency in practical human terms. It is best known publicly as a racehorse doping agent (“frog juice”), banned by WADA and racing authorities.
What does it do in my body?
Dermorphin is a selective µ-opioid receptor agonist with very high analgesic potency. It acts on the same receptor as morphine, fentanyl, and heroin — which is exactly why the caution applies: µ-opioid agonism brings the full opioid liability with it, regardless of the fact that the molecule itself is a peptide rather than a classic opioid alkaloid.
How can it help me?
- Where the science stands: Animal pharmacology strong (30 studies); review-level human discussion; zero controlled human trials
The full evidence — every human, animal, and lab study, graded — is one tap away: use the See the deeper science → toggle at the top.
Is it dangerous? What are the side effects?
Dermorphin is an opioid. A µ-opioid agonist of this potency carries respiratory depression, physical dependence, tolerance, and overdose risk — and dependence was demonstrated directly in the 1985 rat study cited above. Per the 0035 deep-research pass: an opioid agonist with a respiratory-depression and dependence profile does not belong in a consumer-recommendable surface under any goal; it is encyclopedia-only as a curiosity. Dermorphin was previously mis-tagged in an older directory pass under a “sexual-function” category — that tag has been removed; dermorphin has nothing to do with libido. OHM does not recommend it. It belongs in the encyclopedia as a real and pharmacologically remarkable compound — and as a clear example of why a “research peptide” label does not mean low-risk.
Regulatory status: Research compound, not approved for human use; the only real human use is illicit analgesia/doping. Tier B / safety RED / no consumer-goal mapping.
Typical dosing
Talk to your medical provider before starting any protocol. That said, here are the doses most people commonly use — shared for educational purposes so you can have an informed conversation. These peptides are sold for research use only and are not FDA-approved drugs, and this isn't medical advice.
There is no legitimate self-directed protocol to give, and it would be irresponsible to imply one. The only documented real-world human use of dermorphin is illicit analgesia and equine doping — not a consumer wellness or performance protocol. Any dosing figures that circulate outside veterinary-doping and forensic contexts are not backed by legitimate human trial data.
What should I avoid combining — and what's synergistic?
Dermorphin doesn't have a dedicated stacking protocol in our notes — the interactions that matter most are in the safety section above. For how people combine it with other peptides, the deeper-science view has the full detail.
How can I buy this?
We don't have a verified affiliate source for Dermorphin yet, so there's no coupon or vendor link here — we won't point you to a seller we haven't vetted. When buying any research-use-only peptide, the single biggest variable is the supply chain: insist on a vendor that publishes third-party Certificates of Analysis (COAs) confirming identity and >99% purity. Working with a peptide-literate clinician is one solid route — see our provider directory — or check back as our verified sources list grows.
A naturally occurring opioid heptapeptide from frog skin, extraordinarily potent as a µ-opioid receptor agonist — and, precisely because of that, a compound OHM does not recommend under any framing. Real pharmacology, real dependence risk, documented plainly.
| Class | Naturally occurring opioid heptapeptide, first isolated from Phyllomedusa (South American) frog skin |
| Mechanism (one line) | Selective µ-opioid receptor agonist — the same receptor as morphine, fentanyl, and heroin |
| Evidence base | Animal pharmacology strong (30 studies); review-level human discussion; zero controlled human trials |
| Safety record | Dependence and tolerance demonstrated directly in animal models; full opioid liability (respiratory depression, dependence, tolerance, overdose risk) |
| Regulatory status | Research compound; not approved for human use; only real human use is illicit analgesia/doping — banned by WADA and racing authorities |
What it is
Dermorphin is a naturally occurring opioid heptapeptide first isolated from the skin of Phyllomedusa (South American) frogs. It is an extraordinarily potent selective µ-opioid receptor agonist — the foundational pharmacology paper behind it put its potency at ~752–2,170× the potency of morphine in animal models, with the 0035 deep-research categorization pass summarizing it as ~40× morphine potency in practical human terms. It is best known publicly as a racehorse doping agent (“frog juice”), banned by WADA and racing authorities.
How it works
Dermorphin is a selective µ-opioid receptor agonist with very high analgesic potency. It acts on the same receptor as morphine, fentanyl, and heroin — which is exactly why the caution applies: µ-opioid agonism brings the full opioid liability with it, regardless of the fact that the molecule itself is a peptide rather than a classic opioid alkaloid.
What the research shows
The evidence is graded “emerging” (30 studies, 0 human trials) — meaning real animal pharmacology plus review-level human discussion, but no controlled human trials. The 0035 pass grades it Tier B (animal opioid-receptor data + illicit human use). Representative citations (all):
- Broccardo M, et al. — Br J Pharmacol 1981 — potent analgesia 752–2,170× morphine. 7195758
- Broccardo M, et al. — Eur J Pharmacol 1985 — dermorphin induced tolerance and physical dependence in rats, similar to morphine. 4040026 — this is the dependence signal, stated plainly.
- Hesselink JMK & Schatman ME — J Pain Res 2018 review — intrathecal dermorphin showed superior analgesic efficacy vs morphine in postoperative pain. 30538538
Real-world protocol
There is no legitimate self-directed protocol to give, and it would be irresponsible to imply one. The only documented real-world human use of dermorphin is illicit analgesia and equine doping — not a consumer wellness or performance protocol. Any dosing figures that circulate outside veterinary-doping and forensic contexts are not backed by legitimate human trial data.
Side effects & management
Dermorphin is an opioid. A µ-opioid agonist of this potency carries respiratory depression, physical dependence, tolerance, and overdose risk — and dependence was demonstrated directly in the 1985 rat study cited above. Per the 0035 deep-research pass: an opioid agonist with a respiratory-depression and dependence profile does not belong in a consumer-recommendable surface under any goal; it is encyclopedia-only as a curiosity. Dermorphin was previously mis-tagged in an older directory pass under a “sexual-function” category — that tag has been removed; dermorphin has nothing to do with libido. OHM does not recommend it. It belongs in the encyclopedia as a real and pharmacologically remarkable compound — and as a clear example of why a “research peptide” label does not mean low-risk.
Regulatory status
Research compound, not approved for human use; the only real human use is illicit analgesia/doping. Tier B / safety RED / no consumer-goal mapping.
Sources
- (thepeptidelist.com directory capture, 2026-06-07)
- Tier B / RED grading, de-mapping from “sexual-function,” ~40× morphine potency summary
- PMIDs 7195758, 4040026, 30538538 — all
- Migrated from
frontier-investigational-peptides-cluster.md(Section 2)
Sources & references
- (thepeptidelist.com directory capture, 2026-06-07)
- Tier B / RED grading, de-mapping from “sexual-function,” ~40× morphine potency summary
- PMIDs 7195758, 4040026, 30538538 — all
- Migrated from
frontier-investigational-peptides-cluster.md(Section 2)