Syn-Ake
What do these badges mean?
Evidence tier
- AHuman-validated — Human trials showing positive results and good safety.
- BAnimal-grade — No human trials yet, but solid animal/preclinical evidence of effect and safety.
- CAnecdotal — No human or animal trials — only anecdotal/observational reports.
- DInsufficient evidence — No or insufficient evidence (encyclopedia only — never recommended by the builder).
Safety light
- 🟢 Green — Only mild, manageable side effects; reasonable safety data.
- 🟡 Yellow — Needs active management, has a meaningful contraindication/interaction, or has thin long-term data.
- 🔴 Red — Risk of a hospital-level event — treat with serious caution.
Browse-only — not on the protocol builder's curated shortlist, so the builder won't recommend it.
What is it?
Syn-Ake is marketed as the “snake-venom cream” ingredient — a synthetic peptide designed to mimic a genuine venom-derived molecule rather than an actual venom extract, in the same neuromuscular-relaxer family as Argireline (acetyl Hexapeptide-3), SNAP-8, Vialox, and Pentapeptide-18.
What does it do in my body?
Syn-Ake mimics Waglerin-1, a peptide from temple-viper venom, to competitively antagonize nicotinic acetylcholine receptors (nAChR) at the neuromuscular junction, reducing contraction frequency — the same neuromuscular-junction target as Vialox, approached from a different molecular angle.
How can it help me?
- Where the science stands: Anecdotal, but with 1 in-vitro/in-silico study; OHM’s 0035 grading is more favorable (Tier C) than the bare public record
The full evidence — every human, animal, and lab study, graded — is one tap away: use the See the deeper science → toggle at the top.
Is it dangerous? What are the side effects?
No adverse-effect data specific to Syn-Ake was captured in the source profile. Family-wide read: topical delivery carries a benign safety record.
Regulatory status: Cosmetic-grade OTC topical ingredient — not an FDA-reviewed drug.
Typical dosing
Talk to your medical provider before starting any protocol. That said, here are the doses most people commonly use — shared for educational purposes so you can have an informed conversation. These peptides are sold for research use only and are not FDA-approved drugs, and this isn't medical advice.
Topical-only cosmetic ingredient, formulated into leave-on serums alongside other neuro-relaxer peptides. No specific concentration was captured in the source profile.
What should I avoid combining — and what's synergistic?
Syn-Ake doesn't have a dedicated stacking protocol in our notes — the interactions that matter most are in the safety section above. For how people combine it with other peptides, the deeper-science view has the full detail.
How can I buy this?
We don't have a verified affiliate source for Syn-Ake yet, so there's no coupon or vendor link here — we won't point you to a seller we haven't vetted. When buying any research-use-only peptide, the single biggest variable is the supply chain: insist on a vendor that publishes third-party Certificates of Analysis (COAs) confirming identity and >99% purity. Working with a peptide-literate clinician is one solid route — see our provider directory — or check back as our verified sources list grows.
The “snake-venom cream” ingredient — a synthetic mimic of a real temple-viper venom peptide, with a genuine (if shallow) in-vitro study behind it and a more favorable internal OHM read than the bare PubMed record shows.
| Class | Neuromuscular “Botox-like” relaxer — topical cosmetic peptide |
| Mechanism (one line) | Mimics Waglerin-1 (temple-viper venom) → competitively antagonizes nicotinic acetylcholine receptors (nAChR) at the neuromuscular junction → reduced contraction frequency |
| Evidence base | Anecdotal, but with 1 in-vitro/in-silico study; OHM’s 0035 grading is more favorable (Tier C) than the bare public record |
| Safety record | Topical-only; benign safety record (Safety: green) |
| Regulatory status | Cosmetic-grade OTC skincare ingredient, not an FDA-reviewed drug |
What it is
Syn-Ake is marketed as the “snake-venom cream” ingredient — a synthetic peptide designed to mimic a genuine venom-derived molecule rather than an actual venom extract, in the same neuromuscular-relaxer family as Argireline (acetyl Hexapeptide-3), SNAP-8, Vialox, and Pentapeptide-18.
How it works
Syn-Ake mimics Waglerin-1, a peptide from temple-viper venom, to competitively antagonize nicotinic acetylcholine receptors (nAChR) at the neuromuscular junction, reducing contraction frequency — the same neuromuscular-junction target as Vialox, approached from a different molecular angle.
What the research shows
The public profile grades Syn-Ake Anecdotal, but with a single study attached: “Anti-aging activity of Syn-Ake peptide by in silico approaches and in vitro tests” (Gok et al., 2024, PMID 37349941). No human trials are on the profile.
OHM’s internal 0035 categorization pass graded Syn-Ake Tier C / green and recommend-eligible, citing small topical RCTs reporting a muscle-relaxant effect on expression lines (per, attributed to Pentapharm/DSM) — a more favorable read than the bare PubMed record on its own.
Real-world protocol
Topical-only cosmetic ingredient, formulated into leave-on serums alongside other neuro-relaxer peptides. No specific concentration was captured in the source profile.
Side effects & management
No adverse-effect data specific to Syn-Ake was captured in the source profile. Family-wide read: topical delivery carries a benign safety record.
Regulatory status
Cosmetic-grade OTC topical ingredient — not an FDA-reviewed drug.
Sources
- (thepeptidelist.com directory, captured 2026-06-07) — profile grade: Anecdotal, 1 in-vitro study, 0 human trials. Study cited: Gok et al., 2024, PMID 37349941.
- OHM tier/safety grading: Tier C / green / recommend-eligible, citing Pentapharm/DSM topical RCTs.
- Migrated from
cosmetic-topical-peptides-cluster.md(2026-06-10 cluster build) as part of the cluster-to-standalone-article migration.
Related: Argireline (acetyl Hexapeptide-3) · SNAP-8 · Vialox · Pentapeptide-18
Sources & references
- (thepeptidelist.com directory, captured 2026-06-07) — profile grade: Anecdotal, 1 in-vitro study, 0 human trials. Study cited: Gok et al., 2024, PMID 37349941.
- OHM tier/safety grading: Tier C / green / recommend-eligible, citing Pentapharm/DSM topical RCTs.
- Migrated from
cosmetic-topical-peptides-cluster.md(2026-06-10 cluster build) as part of the cluster-to-standalone-article migration.
Related: Argireline (acetyl Hexapeptide-3) · SNAP-8 · Vialox · Pentapeptide-18