Vilon
What do these badges mean?
Evidence tier
- AHuman-validated — Human trials showing positive results and good safety.
- BAnimal-grade — No human trials yet, but solid animal/preclinical evidence of effect and safety.
- CAnecdotal — No human or animal trials — only anecdotal/observational reports.
- DInsufficient evidence — No or insufficient evidence (encyclopedia only — never recommended by the builder).
Safety light
- 🟢 Green — Only mild, manageable side effects; reasonable safety data.
- 🟡 Yellow — Needs active management, has a meaningful contraindication/interaction, or has thin long-term data.
- 🔴 Red — Risk of a hospital-level event — treat with serious caution.
Browse-only — not on the protocol builder's curated shortlist, so the builder won't recommend it.
What is it?
Vilon is a synthetic dipeptide (Lys-Glu / KE) — the immune/geroprotective member of the Khavinson short-peptide bioregulator family with the most human studies after the family prototype, Thymalin. Site tier is graded Strong (20 studies, 3–6 human — the site’s own counts are internally inconsistent), with the highest trial phase listed as Phase 3.
What does it do in my body?
Claimed mechanism: influences thymic gene expression and immune-cell development. In the chromatin work, Vilon behaves like the rest of the Khavinson family — selective heterochromatin decondensation and gene reactivation in elderly lymphocytes, consistent with the family-wide theoretical claim that short tissue-derived peptides cross cell and nuclear membranes to bind DNA and modulate transcription in a tissue-specific way (Fedoreyeva et al. 2011, Biochemistry (Mosc), 22117547; Khavinson, Lezhava, Malinin 2004, Bull Exp Biol Med, 15085253).
How can it help me?
- Where the science stands: Site tier graded Strong (20 studies, 3–6 human — the site’s own counts are internally inconsistent); highest trial phase listed as Phase 3
The full evidence — every human, animal, and lab study, graded — is one tap away: use the See the deeper science → toggle at the top.
Is it dangerous? What are the side effects?
The reported adverse-event profile across the family is mild and uncommon in the Russian literature: occasional injection-site reactions, transient mild headache early in a cycle. No serious AEs documented at standard doses.
The real risk isn’t the molecule — it’s the supply chain. Khavinson-family peptides are the dominant gray-market counterfeit category in the peptide space. Buyers typically source these from forum links with no way to verify identity or purity, and counterfeit/mislabeled product is the most common failure mode for exactly these compounds. Third-party COA verification matters more here than for almost any other peptide class.
Regulatory status: Vilon is research_only in the US — not FDA-approved for human use, sold as a research compound, not eligible for compounding. It is not a controlled substance. Note that the family prototype, Thymalin (and the related cortex peptide Cortexin), holds a clinical-use approval in Russia — that approval does not extend to Vilon or to the US.
Part 1 — How to reconstitute it
What you'll need: bacteriostatic water (sterile, preserved water you mix the powder with) and a separate, larger reconstitution syringe just for mixing — not the small syringe you inject with.
The exact bacteriostatic-water volume and resulting concentration for Vilon are covered in the dosing notes and the deeper-science view. Confirm the right volume for your vial before mixing.
How to mix it
- Tilt the vial and let the bacteriostatic water run slowly down the inside glass wall — never squirt it straight onto the powder.
- Swirl gently to dissolve. Never shake — shaking can damage the peptide.
- Store the reconstituted vial refrigerated and out of light.
- Use it within the beyond-use window your source specifies — reconstituted peptides are commonly used within a few weeks; confirm the window for your specific peptide.
Use the free reconstitution calculator to turn any vial size + water volume into exact units on an insulin syringe.
Part 2 — Typical dosing
Talk to your medical provider before starting any protocol. That said, here are the doses most people commonly use — shared for educational purposes so you can have an informed conversation. These peptides are sold for research use only and are not FDA-approved drugs, and this isn't medical advice.
The syringe. Use a 0.3 mL U-100 insulin syringe — it's sized for these small subcutaneous doses. Inject subcutaneously (into the fat just under the skin) and rotate injection sites.
Educational purposes only — this reflects what Russian-school protocols and the peptide community actually use, stated plainly; it is not medical advice.
There is no Western-validated dosing protocol for Vilon. What exists is the Khavinson-school cycle pattern shared across the family:
- Cycle structure: a short course — typically 10–20 consecutive days — followed by a long rest, repeated 2–3 times per year. The framework claims effects persist 2–3 months past the end of a cycle — asserted by the Khavinson program, not independently confirmed.
- Dose: as a synthetic short dipeptide, community subcutaneous dosing converges around ~100–200 mcg/day over the 10–20 day cycle; some Khavinson-family short peptides are also sold as oral capsules or sublingual drops in the Russian retail market per-peptide specifics.
- Storage: lyophilized powder is stable cold; once reconstituted with bacteriostatic water, refrigerate and use within roughly 28 days.
Because per-peptide human dose-finding data doesn’t exist for this family, treat every number above as community/Russian-protocol convergence, not a validated dose.
Turning milligrams into syringe units. On a U-100 syringe, 100 units = 1 mL, so 1 unit = 0.01 mL. At a concentration of C mg/mL, a dose of D mg = D ÷ C mL = (D ÷ C) × 100 units. Example: at 5 mg/mL, a 0.5 mg dose = 0.1 mL = 10 units. Your exact units depend on your own vial's mg and how much bacteriostatic water you added — use the same concentration you mixed above.
What should I avoid combining — and what's synergistic?
Vilon doesn't have a dedicated stacking protocol in our notes — the interactions that matter most are in the safety section above. For how people combine it with other peptides, the deeper-science view has the full detail.
How can I buy this?
Vilon is available from BioLongevity Labs — use code OHM-15 at BioLongevity for 15% off. As always, buy only from a source that publishes third-party Certificates of Analysis (COAs) confirming identity and >99% purity.
When you use my coupon code to buy peptides with these sellers, you enjoy a discount off retail price, and I make a small commission which helps me to continue to offer this peptide educational site to you for free. I only have affiliate relationships with peptide manufacturers that show evidence that their peptides are 100% manufactured in the US, 3rd party lab tested for purity, transparent COAs posted on their websites, and that have good customer service.
Vilon (Lys-Glu) is the Khavinson-family immune/geroprotective dipeptide with the most human studies after Thymalin — a genuine Russian cohort record plus a strong in-vitro epigenetics line. The 0035 pass still judged the per-indication evidence too thin to anchor a primary recommendation, despite the higher study count. Both the depth and the limit are worth stating honestly.
| Class | Synthetic dipeptide — Lys-Glu (KE) |
| Mechanism (one line) | Influences thymic gene expression and immune-cell development; drives heterochromatin decondensation and gene reactivation in aging cells |
| Evidence base | Site tier graded Strong (20 studies, 3–6 human — the site’s own counts are internally inconsistent); highest trial phase listed as Phase 3 |
| Safety record | No serious AEs documented in the Russian literature; Safety Green |
| Regulatory status | research_only in the US, not FDA-approved |
What it is
Vilon is a synthetic dipeptide (Lys-Glu / KE) — the immune/geroprotective member of the Khavinson short-peptide bioregulator family with the most human studies after the family prototype, Thymalin. Site tier is graded Strong (20 studies, 3–6 human — the site’s own counts are internally inconsistent), with the highest trial phase listed as Phase 3.
How it works
Claimed mechanism: influences thymic gene expression and immune-cell development. In the chromatin work, Vilon behaves like the rest of the Khavinson family — selective heterochromatin decondensation and gene reactivation in elderly lymphocytes, consistent with the family-wide theoretical claim that short tissue-derived peptides cross cell and nuclear membranes to bind DNA and modulate transcription in a tissue-specific way (Fedoreyeva et al. 2011, Biochemistry (Mosc), 22117547; Khavinson, Lezhava, Malinin 2004, Bull Exp Biol Med, 15085253).
What the research shows
Russian human cohorts plus a strong in-vitro chromatin/epigenetics line (all pending citation-verification pass):
- Kuznik et al. 2007, Adv Gerontol — improved coagulation and immune markers, reduced insulin requirements in elderly diabetics. 18306698.
- Kuznik et al. 2006 — reduced DIC syndrome in type-1 diabetes. 17152731.
- Ias’kevich et al. 2005 — improved survival / fewer complications in elderly stage-III colorectal cancer patients. 16075684 case series.
- Epigenetic in-vitro: the “KE peptide” (Vilon) increased SIRT1 and decreased PARP1/PARP2 expression in aging human MSCs (Khavinson, Linkova et al. 2023, Adv Gerontol, 37782636); selective heterochromatin decondensation in elderly lymphocytes (Lezhava et al. 2023, Georgian Med News, 37042594).
OHM grade: C / green — SECONDARY longevity + SECONDARY immune (no PRIMARY: the 0035 pass judged the per-indication evidence too thin to anchor a primary goal, despite the higher study count than the rest of the provisional set).
Immune-group cross-link. The thymic-immune target overlaps conceptually with Thymosin Alpha-1 — a separate, far better Western-evidenced thymic immune peptide (a 28-amino-acid thymosin fragment with real human trial data and active research-vendor availability). A reader wanting a thymus/immune peptide they can buy today from a verified-COA vendor is better served by Thymosin alpha-1; Vilon and its siblings Thymalin and Thymagen are the deeper-history, Russian-school context around it.
Real-world protocol
Educational purposes only — this reflects what Russian-school protocols and the peptide community actually use, stated plainly; it is not medical advice.
There is no Western-validated dosing protocol for Vilon. What exists is the Khavinson-school cycle pattern shared across the family:
- Cycle structure: a short course — typically 10–20 consecutive days — followed by a long rest, repeated 2–3 times per year. The framework claims effects persist 2–3 months past the end of a cycle — asserted by the Khavinson program, not independently confirmed.
- Dose: as a synthetic short dipeptide, community subcutaneous dosing converges around ~100–200 mcg/day over the 10–20 day cycle; some Khavinson-family short peptides are also sold as oral capsules or sublingual drops in the Russian retail market per-peptide specifics.
- Storage: lyophilized powder is stable cold; once reconstituted with bacteriostatic water, refrigerate and use within roughly 28 days.
Because per-peptide human dose-finding data doesn’t exist for this family, treat every number above as community/Russian-protocol convergence, not a validated dose.
Side effects & management
The reported adverse-event profile across the family is mild and uncommon in the Russian literature: occasional injection-site reactions, transient mild headache early in a cycle. No serious AEs documented at standard doses.
The real risk isn’t the molecule — it’s the supply chain. Khavinson-family peptides are the dominant gray-market counterfeit category in the peptide space. Buyers typically source these from forum links with no way to verify identity or purity, and counterfeit/mislabeled product is the most common failure mode for exactly these compounds. Third-party COA verification matters more here than for almost any other peptide class.
Regulatory status
Vilon is research_only in the US — not FDA-approved for human use, sold as a research compound, not eligible for compounding. It is not a controlled substance. Note that the family prototype, Thymalin (and the related cortex peptide Cortexin), holds a clinical-use approval in Russia — that approval does not extend to Vilon or to the US.
Sources
- primary profile (thepeptidelist.com directory capture, 2026-06-07).
- 0035 tier/safety/goal grading: Vilon promoted to C-green.
- Vilon human/in-vitro PMIDs: 18306698, 17152731, 16075684, 37782636, 37042594 — all pending citation-verification pass.
- Family-mechanism PMIDs: 22117547 (Fedoreyeva et al. 2011), 15085253 (Khavinson/Lezhava/Malinin 2004).
- Related: Thymalin · Thymagen · Thymosin Alpha-1 · the Khavinson bioregulator family.
Sources & references
- primary profile (thepeptidelist.com directory capture, 2026-06-07).
- 0035 tier/safety/goal grading: Vilon promoted to C-green.
- Vilon human/in-vitro PMIDs: 18306698, 17152731, 16075684, 37782636, 37042594 — all pending citation-verification pass.
- Family-mechanism PMIDs: 22117547 (Fedoreyeva et al. 2011), 15085253 (Khavinson/Lezhava/Malinin 2004).
- Related: Thymalin · Thymagen · Thymosin Alpha-1 · the Khavinson bioregulator family.